Searchable abstracts of presentations at key conferences in endocrinology

ea0063oc3.3 | Cushing's and acromegaly | ECE2019

Monosynaptic inputs to corticotropin-releasing hormone neuron in hypothalamic paraventricular nucleus of mice at the whole brain scale

Wang Yu , Zhou Jiang-Ning

Corticotropin-releasing hormone (CRH), a 41-aminoacid peptide that is mainly produced in the hypothalamic paraventricular nucleus (PVN), plays a crucial role in stress response and is considered to be the central driving force in the activity of hypothalamic–pituitary–adrenal (HPA) axis. Previous studies of neuronal input to the PVN were limited by experimental techniques and could not be restricted by a single neuron type. In the present study, by using a novel defi...